Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase.
Abstract
Tissue transglutaminase (TG2) is involved in Ca(2+)-dependent aggregation and polymerization of proteins. We previously reported that TG2 mRNA is up-regulated in epithelial ovarian cancer (EOC) cells compared with normal ovarian epithelium. Here, we show overexpression of the TG2 protein in ovarian cancer cells and tumors and its secretion in ascites fluid and define its role in EOC. By stable knockdown and overexpression, we show that TG2...
Paper Details
Title
Enhanced peritoneal ovarian tumor dissemination by tissue transglutaminase.
Published Date
Aug 1, 2007
Journal
Volume
67
Issue
15
Pages
7194 - 7202
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