Addition of HOBt improves the conversion of thioester-Amine chemical ligation
Abstract
The syntheses of large peptides and of those containing non-natural amino acids can be facilitated by the application of convergent approaches, dissecting the native sequence into segments connected through a ligation reaction. We describe an improvement of the ligation protocol used to prepare peptides and proteins without cysteine residues at the ligation junction. We have found that the addition of HOBt to the ligation, improves the...
Paper Details
Title
Addition of HOBt improves the conversion of thioester-Amine chemical ligation
Published Date
Nov 1, 2015
Journal
Volume
104
Issue
6
Pages
693 - 702
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