A Chemical Biological Strategy to Facilitate Diabetic Wound Healing
Abstract
A complication of diabetes is the inability of wounds to heal in diabetic patients. Diabetic wounds are refractory to healing due to the involvement of activated matrix metalloproteinases (MMPs), which remodel the tissue resulting in apoptosis. There are no readily available methods that identify active unregulated MMPs. With the use of a novel inhibitor-tethered resin that binds exclusively to the active forms of MMPs, coupled with proteomics,...
Paper Details
Title
A Chemical Biological Strategy to Facilitate Diabetic Wound Healing
Published Date
Sep 26, 2013
Journal
Volume
9
Issue
1
Pages
105 - 110
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