In Utero Exposure to Phthalate Downregulates Critical Genes in Leydig Cells of F1 Male Progeny
Volume: 116, Issue: 7, Pages: 1466 - 1477
Published: May 12, 2015
Abstract
Phthalates are the largest group of environmental pollutants and are considered toxicant to the endocrine system. The present study was aimed to test the effect of in utero exposure of di(2‐ethylhexyl)phthalate (DEHP) on Leydig cell steroidogenesis in F 1 male offspring's. Pregnant dams were oral gavaged with different doses (1, 10, and 100 mg/kg/day) of DEHP or olive oil during gestational Day 9–21. Serum testosterone (T) and estradiol (E 2 )...
Paper Details
Title
In Utero Exposure to Phthalate Downregulates Critical Genes in Leydig Cells of F1 Male Progeny
Published Date
May 12, 2015
Volume
116
Issue
7
Pages
1466 - 1477
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