Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity
Abstract
The increasing incidence of obesity accentuates the importance of identifying mechanisms and optimal therapeutic strategies for patients with heart failure (HF) in relation to obesity status. Here, we investigated the association between plasma level of apelin, an adipocyte-derived factor, and clinicopathological features of obese and non-obese patients with HF. We further explored potential regulatory mechanisms of cardiac cell fate responses...
Paper Details
Title
Apelin regulates FoxO3 translocation to mediate cardioprotective responses to myocardial injury and obesity
Published Date
Nov 6, 2015
Journal
Volume
5
Issue
1
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