The acinar regulator Gata6 suppressesKrasG12V-driven pancreatic tumorigenesis in mice
Abstract
Gata6 is required to complete and maintain acinar differentiation in the mouse pancreas. Pancreas-specific Gata6 ablation during development causes extensive and persistent acinar-ductal metaplasia, which is considered an initial step of mutant KRas-driven carcinogenesis. Therefore, the Gata6-null pancreas might represent a tumour-prone environment. We investigated whether Gata6 plays a role during pancreatic tumorigenesis.We analysed...
Paper Details
Title
The acinar regulator Gata6 suppressesKrasG12V-driven pancreatic tumorigenesis in mice
Published Date
Jan 16, 2015
Journal
Volume
65
Issue
3
Pages
476 - 486
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