A HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia
Abstract
Acute promyelocytic leukemia (APL) is a sub-type of acute myeloid leukemia (AML) characterized by a block of myeloid differentiation at the promyelocytic stage and the predominant t(15:17) chromosomal translocation. We have previously determined that cells from APL patients show increased expression of genes regulated by hypoxia-inducible transcription factors (HIFs) compared to normal promyelocytes. HIFs regulate crucial aspects of solid tumor...
Paper Details
Title
A HIF-1 network reveals characteristics of epithelial-mesenchymal transition in acute promyelocytic leukemia
Published Date
Dec 1, 2014
Journal
Volume
6
Issue
12
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