Developmental Exposure to TCDD Alters Endometrial Expression of Progesterone Receptor and Reduces Differentiation-Related TGF-β2 Expression in Adult Mice

Animal studies demonstrate that exposure to the environmental contaminant 2,3,7,8-tetracholorodibenzo-p-dioxin (TCDD) can both disrupt maternal pregnancy and impair important cellular processes in the developing offspring. Although the impact of TCDD exposure on human development in utero is less clear, developmental exposure to this toxin may impact the development of adult diseases, including endometriosis. Using a chimeric model of...