Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Abstract
Mesenchymal stem cells have been recently described to localize to breast carcinomas, where they integrate into the tumour-associated stroma. However, the involvement of mesenchymal stem cells (or their derivatives) in tumour pathophysiology has not been addressed. Here, we demonstrate that bone-marrow-derived human mesenchymal stem cells, when mixed with otherwise weakly metastatic human breast carcinoma cells, cause the cancer cells to...
Paper Details
Title
Mesenchymal stem cells within tumour stroma promote breast cancer metastasis
Published Date
Oct 4, 2007
Journal
Volume
449
Issue
7162
Pages
557 - 563
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Notes
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