Fibroblast Growth Factor Homologous Factors Modulate Cardiac Calcium Channels

Rationale : Fibroblast growth factor (FGF) homologous factors (FHFs; FGF11–14) are intracellular modulators of voltage-gated Na + channels, but their cellular distribution in cardiomyocytes indicated that they performed other functions. Objective : We aimed to uncover novel roles for FHFs in cardiomyocytes, starting with a proteomic approach to identify novel interacting proteins. Methods and Results : Affinity purification of FGF13 from rodent...