Matrix metalloproteinase-2 of human carotid atherosclerotic plaques promotes platelet activation
Abstract
Summary Purified active matrix metalloproteinase-2 (MMP-2) is able to promote platelet aggregation. We aimed to assess the role of MMP-2 expressed in atherosclerotic plaques in the platelet-activating potential of human carotid plaques and its correlation with ischaemic events. Carotid plaques from 81 patients undergoing endarterectomy were tested for pro-MMP-2 and TIMP-2 content by zymography and ELISA. Plaque extracts were incubated with...
Paper Details
Title
Matrix metalloproteinase-2 of human carotid atherosclerotic plaques promotes platelet activation
Published Date
Jan 1, 2014
Journal
Volume
111
Issue
06
Pages
1089 - 1101
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