Emerging Links between E2F Control and Mitochondrial Function
Abstract
The family of E2F transcription factors is the key downstream target of the retinoblastoma tumor suppressor protein (pRB), which is frequently inactivated in human cancer. E2F is best known for its role in cell-cycle regulation and triggering apoptosis. However, E2F binds to thousands of genes and, thus, could directly influence a number of biologic processes. Given the plethora of potential E2F targets, the major challenge in the field is to...
Paper Details
Title
Emerging Links between E2F Control and Mitochondrial Function
Published Date
Feb 15, 2015
Journal
Volume
75
Issue
4
Pages
619 - 623
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