Elevated thyroid stimulating hormone is associated with elevated cortisol in healthy young men and women

Published on Oct 30, 2012in Thyroid Research
· DOI :10.1186/1756-6614-5-13
Kimberly N. Walter8
Estimated H-index: 8
(PSU: Pennsylvania State University),
Elizabeth J. Corwin30
Estimated H-index: 30
(Emory University)
+ 4 AuthorsLaura Cousino Klein30
Estimated H-index: 30
(PSU: Pennsylvania State University)
Sources
Abstract
Background: Recent attention has been given to subclinical hypothyroidism, defined as an elevation of TSH (4.5-10 uIU/L) with T4 and T3 levels still within the normal range. Controversy exists about the proper lower limit of TSH that defines patients in the subclinical hypothyroidism range and about if/when subclinical hypothyroidism should be treated. Additional data are needed to examine the relationship between markers of thyroid function in the subclinical hypothyroidism range, biomarkers of health and ultimately health outcomes. Objective: We aimed to assess the relationship between serum TSH levels in the 0.5-10 uIU/L range and serum cortisol in a cohort of healthy young men and women without clinical evidence of hypothyroidism. Based on data in frank hypothyroidism, we hypothesized that serum TSH levels would be positively correlated with serum cortisol levels, suggesting derangement of the cortisol axis even in subclinical hypothyroidism. Methods: We conducted a cross sectional study in 54 healthy, young (mean 20.98 +/− 0.37 yrs) men (19) and women (35). Lab sessions took place at 1300 hrs where blood was drawn via indwelling catheter for later assessment of basal serum TSH, free T3, free T4, and cortisol levels. Results: All but 1 participant had free T3 levels within the normal reference intervals; free T4 levels for all participants were within the normal reference intervals. Linear regression modeling revealed that TSH levels in the 0.5-10 uIU/L were significantly and positively correlated with cortisol levels. This positive TSH-cortisol relationship was maintained below the accepted 4.5 uIU/L subclinical hypothyroid cutoff. Separate regression analyses conducted by systematically dropping the TSH cutoff by 0.50 uIU/L revealed that the TSH-cortisol relationship was maintained for TSH levels (uIU/L) ≤4.0, ≤3.5, ≤3.0, and ≤2.5 but not ≤2.0. Linear regression modeling did not reveal a relationship between free T3 or free T4 levels and cortisol levels. Conclusions: Results suggest a positive relationship between TSH and cortisol in apparently healthy young individuals. In as much as this relationship may herald a pathologic disorder, these preliminary results suggest that TSH levels > 2.0 uIU/L may be abnormal. Future research should address this hypothesis further, for instance through an intervention study.
📖 Papers frequently viewed together
References24
Newest
#1FatourechiH-Index: 1
Source
Subclinical hypothyroidism (SCH), also called mild thyroid failure, is diagnosed when peripheral thyroid hormone levels are within normal reference laboratory range but serum thyroid-stimulating hormone (TSH) levels are mildly elevated. This condition occurs in 3% to 8% of the general population. It is more common in women than men, and its prevalence increases with age. Of patients with SCH, 80% have a serum TSH of less than 10 mIU/L. The most important implication of SCH is high likelihood of ...
Source
#1Carole A. Spencer (SC: University of Southern California)H-Index: 54
#2Joseph G. Hollowell (KU: University of Kansas)H-Index: 17
Last. Lewis E. Braverman (BU: Boston University)H-Index: 93
view all 4 authors...
Context: The setting of the TSH upper reference limit impacts the diagnosis of mild hypothyroidism and is currently controversial. Objective: Our objective was to evaluate factors influencing the TSH reference range. Design: Nonpregnant subjects aged 12 yr and older from National Health and Nutrition Examination Survey III were used to study the relationships between TSH, thyroid peroxidase antibodies (TPOAb), and thyroglobulin antibodies in different ethnic groups. Results: TPOAb prevalence was...
Source
#1Cloyra Almeida (UFRJ: Federal University of Rio de Janeiro)H-Index: 12
#2Marco Antonio Alves Brasil (UFRJ: Federal University of Rio de Janeiro)H-Index: 14
Last. Mario Vaisman (UFRJ: Federal University of Rio de Janeiro)H-Index: 36
view all 12 authors...
OBJETIVO: Avaliar a prevalencia de sintomas e alteracoes psiquiatricas em pacientes com hipotireoidismo subclinico. METODO: Foram estudados 94 pacientes ambulatoriais com pelo menos duas dosagens plasmaticas elevadas de tireotropina (> 4 µU/ml) e com T4 livre normal e, 43 eutireoidianos, ambos os grupos do HUCFF-UFRJ. Para diagnostico psiquiatrico foi utilizada a entrevista clinica estruturada do eixo I (SCID-I/DSM-IV) e, para sintomas psicopatologicos, as escalas de ansiedade e depressao de Ham...
Source
#1Robin J. Bell (Alfred Hospital)H-Index: 51
#2Livia Rivera-WollH-Index: 4
Last. Scott Davis (Alfred Hospital)H-Index: 88
view all 6 authors...
Summary Objectives The aim of this study was to evaluate whether subclinical thyroid disease is associated with impaired health-related quality of life and a more adverse cardiovascular disease risk profile. Design A community-based cross-sectional study. Setting and participants A total of 1423 non-healthcare-seeking women, aged 18–75 years were randomly recruited from the community via the electoral roll from April 2002 to August 2003. Main outcome measures These were the scores for the Short-...
Source
#1Courtney A. Whetzel (PSU: Pennsylvania State University)H-Index: 10
#2Elizabeth J. Corwin (OSU: Ohio State University)H-Index: 30
Last. Laura Cousino Klein (PSU: Pennsylvania State University)H-Index: 30
view all 3 authors...
Abstract Interferon (IFN)-γ and IL-10 cytokines, measures of Th1 and Th2 immunity, were examined in 20 healthy nonsmokers (12 males, 8 females) and 19 smokers (11 males, 8 females), aged 19–41 years (23.46 ± 0.82 years). Nonsmokers came to the laboratory once; smokers came to the laboratory after ad lib smoking and following 24-h smoking abstinence. Salivary cotinine and expired CO confirmed smoking status. Plasma was collected at the end of each lab session and assayed for peripheral IFN-γ and ...
Source
#1Kristien Boelaert (University of Birmingham)H-Index: 38
#2Jayne A. FranklynH-Index: 79
Thyroid disease is common, affecting around 2% of women and 0·2% of men in the UK. Our understanding of the effects of thyroid hormones under physiological circumstances, as well as in pathological conditions, has increased dramatically during the last two centuries and it has become clear that overt thyroid dysfunction is associ- ated with significant morbidity and mortality. Both hypo- and hyperthyroidism and their treatments have been linked with increased risk from cardiovascular disease and...
Source
#1Martin I. Surks (Albert Einstein College of Medicine)H-Index: 56
#2Gayotri GoswamiH-Index: 2
Last. Gilbert H. Daniels (Harvard University)H-Index: 58
view all 3 authors...
Context: Recent recommendations to decrease the upper limit of the TSH reference range from 4.5 to 2.5 mIU/liter, based on the high proportion of normal people whose serum TSH is less than 2.5 mIU/liter and the observation that those with TSH between 2.5 and 4.5 mIU/liter [upper reference range (URR)] have increased risk of progression to overt hypothyroidism (Whickham, 20-yr data), have not been subjected to critical analysis. Study Subjects: The study subjects were from the Reference Group of ...
Source
Debate and controversy currently surround the recommendations of a recent consensus conference that considered issues related to the management of early, mild, or so-called subclinical hypothyroidism and hyperthyroidism. Intimately related to the controversy is the definition of the normal reference range for TSH. It has become clear that previously accepted reference ranges are no longer valid as a result of both the development of more highly sensitive TSH assays and the appreciation that refe...
Source
#8Jerome M. Hershman (UCLA: University of California, Los Angeles)H-Index: 59
ContextPatients with serum thyroid-stimulating hormone (TSH) levels outside the reference range and levels of free thyroxine (FT4) and triiodothyronine (T3) within the reference range are common in clinical practice. The necessity for further evaluation, possible treatment, and the urgency of treatment have not been clearly established.ObjectivesTo define subclinical thyroid disease, review its epidemiology, recommend an appropriate evaluation, explore the risks and benefits of treatment and con...
Source
Cited By23
Newest
Source
RESEARCH DESIGN AND METHODS This cross-sectional study was performed on healthy volunteers and those who had been referred with a diagnosis of subclinical hypothyroidism (TSH<10 mIU/L). Subjects with the age of 18-35 years were enrolled. The sera were analyzed for Cortisol, FT4, FT3, TSH, Ani-TPO, and Anti-Tg. RESULTS Final sample of 36 in group A (TSH<2.5), 45 in group B (TSH: 2.5-4.2), and 71 in group C (TSH: 4.3-10) were included. Cortisol levels were significantly different in the three grou...
Source
#1Anzar Alam (National Institute of Unani Medicine)H-Index: 6
#2Mohd Aleemuddin Quamri (National Institute of Unani Medicine)H-Index: 5
Last. Nafis Haider (College of Health Sciences, Bahrain)H-Index: 7
view all 0 authors...
OBJECTIVES Hypothyroidism is the most common disorder arising from hormone deficiency. It frequently affects women than men. The prevalence of overall hypothyroidism has been reported to be 4.8-11%. Levothyroxine is the treatment of choice for all types of hypothyroidism. The purpose of this pilot study was to evaluate the efficacy and safety of Barg-e-Sahajna (Leaves of Moringa oleifera Lam.) among diagnosed patients of primary hypothyroidism. METHODS This study was an open observational study....
Source
#1Raphael HirtzH-Index: 2
#2Lars LibudaH-Index: 22
Last. Corinna GrasemannH-Index: 13
view all 11 authors...
Source
#1N. V. Kuzmenko (First Pavlov State Medical University of St. Peterburg)H-Index: 1
Last. M. G. Pliss (First Pavlov State Medical University of St. Peterburg)H-Index: 2
view all 3 authors...
Currently, most researchers believe that circannual fluctuations in the functioning of the human body relate not so much to fluctuations in melatonin levels as to changes in the ambient temperature. The goal of this work was to study the seasonal dynamics of melatonin, prolactin, sex hormones, and adrenal hormones in healthy people by a meta-analysis of publications and, based on its outcome, to draw a conclusion on the influence of the photoperiod and air temperature on seasonal changes in the ...
Source
#1Rafael Maso Prévide (NIH: National Institutes of Health)H-Index: 2
#2Kai Wang (NIH: National Institutes of Health)
Last. Stanko S. Stojilkovic (NIH: National Institutes of Health)H-Index: 72
view all 6 authors...
Background: Thyrotropin (TSH) is well known as the hormone of the anterior pituitary thyrotrophs responsible for acting in the thyroid gland, where it stimulates synthesis and release of thyroid hormones through Gs and Gq/11 protein coupled TSH receptors (TSHRs). Methods: In this study, we examined whether the functional TSHRs are also expressed in cultured rat pituitary cells, using double immunocytochemistry, quantitative reverse transcription-polymerase chain reaction analysis, cAMP and hormo...
Source
#1Kommaly Onxayvieng (HAU: Huazhong Agricultural University)H-Index: 1
#2Marina Piria (University of Zagreb)H-Index: 15
Last. Dapeng Li (HAU: Huazhong Agricultural University)H-Index: 18
view all 9 authors...
This study investigated the effect of stocking density on growth performance, blood biochemical profiles, antioxidative capacity, and muscle quality of gibel carp (Carassius gibelio). Gibel carps (initial body weight 57.04 ± 1.89 g) were reared at high stocking density (HSD, 10.85 kg m-3), medium stocking density (MSD, 5.06 kg m-3), and low stocking density (LSD, 1.47 kg m-3) for 60 days. The LSD group exhibited the highest growth rate, while HSD significantly inhibited fish growth. The muscular...
Source
#1Yang Quan (Shanghai Ocean University)H-Index: 2
#2Liang Guo (Chinese Academy of Fishery Sciences)H-Index: 9
Last. Dianchang Zhang (Chinese Academy of Fishery Sciences)H-Index: 17
view all 8 authors...
Abstract Golden pompano (Trachinotus ovatus) is one of the most important cultured marine fish in Southeast Asia. Stocking density affects the growth performance and welfare of fish in aquaculture. A 70-day rearing experiment was performed to evaluate the effect of different stocking densities on the growth performance, feed conversion ratio, serum biochemistry, muscle quality, antioxidant capacity and HSP70 mRNA expression of juvenile golden pompano cultured in off-shore sea cages. The experime...
Source
#1Martin Reindl (Innsbruck Medical University)H-Index: 13
#2Hans-Josef Feistritzer (Innsbruck Medical University)H-Index: 18
Last. Bernhard Metzler (Innsbruck Medical University)H-Index: 39
view all 11 authors...
Background:Adverse left ventricular remodeling is one of the major determinants of heart failure and mortality in patients surviving ST-segment elevation myocardial infarction (STEMI). The hypothal...
Source
#1Fatih Ulaş (Abant Izzet Baysal University)H-Index: 8
#2Enes Uyar (Abant Izzet Baysal University)H-Index: 2
Last. Serdal Çelebi (Abant Izzet Baysal University)H-Index: 10
view all 4 authors...
ABSTRACTPurpose: To evaluate selected systemic findings, especially thyroid functions, in acute central serous chorioretinopathy (CSC) patients.Materials and Methods: In all, 71 consecutive acute C...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.