Role of the intracellular domains of CXCR4 in SDF-1–mediated signaling

Blood20.30
Volume: 101, Issue: 2, Pages: 399 - 406
Published: Jan 15, 2003
Abstract
The CXCR4 chemokine receptor is a Gi protein–coupled receptor that triggers multiple intracellular signals in response to stromal cell-derived factor 1 (SDF-1), including calcium mobilization and p44/42 extracellular signal-regulated kinases (ERK1/2). Transduced signals lead to cell chemotaxis and are terminated through receptor internalization depending on phosphorylation of the C terminus part of CXCR4. Receptor endocytosis is also required...
Paper Details
Title
Role of the intracellular domains of CXCR4 in SDF-1–mediated signaling
Published Date
Jan 15, 2003
Journal
Volume
101
Issue
2
Pages
399 - 406
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