Detection of Mutations inEGFRin Circulating Lung-Cancer Cells

The use of tyrosine kinase inhibitors to target the epidermal growth factor receptor gene (EGFR) in patients with non-small-cell lung cancer is effective but limited by the emergence of drug-resistance mutations. Molecular characterization of circulating tumor cells may provide a strategy for noninvasive serial monitoring of tumor genotypes during treatment.We captured highly purified circulating tumor cells from the blood of patients with...