Expansion of CD4+CD25+FoxP3+ regulatory T cells in hepatitis C virus‐related chronic hepatitis, cirrhosis and hepatocellular carcinoma
Abstract
Aim: Regulatory T (Treg) cells may play a pivotal role in the persistence of hepatitis C virus (HCV) infection and the development of hepatocellular carcinoma (HCC). Therefore, we examined their frequency in peripheral blood from patients with HCV-positive chronic hepatitis (CH), cirrhosis (LC) and HCC.
Methods: Treg cells were identified as CD4+, CD25+ and FoxP3+ T lymphocytes using three-color FACS. The frequency of Treg cells was...
Paper Details
Title
Expansion of CD4+CD25+FoxP3+ regulatory T cells in hepatitis C virus‐related chronic hepatitis, cirrhosis and hepatocellular carcinoma
Published Date
Feb 1, 2010
Journal
Volume
40
Issue
2
Pages
179 - 187
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