Early growth response 1 is an early signal inducing Cav3.2 T-type calcium channels during cardiac hypertrophy

The Cav3.2 T-channel plays a pivotal role in inducing calcineurin/nuclear factor of activated T cell (NFAT) signalling during cardiac hypertrophy. Because calcineurin/NFAT signalling is induced early after pressure overload, we hypothesized that Cav3.2 is induced by an early signal. Our aim is to investigate when and how Cav3.2 is induced during cardiac hypertrophy. The evolutionary conserved promoter Cav3.2-3500 from mouse genome was validated...