The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels
Abstract
It is well established that the auxiliary Cavβ subunit regulates calcium channel density in the plasma membrane, but the cellular mechanism by which this occurs has remained unclear. We found that the Cavβ subunit increased membrane expression of Cav1.2 channels by preventing the entry of the channels into the endoplasmic reticulum-associated protein degradation (ERAD) complex. Without Cavβ, Cav1.2 channels underwent robust ubiquitination by the...
Paper Details
Title
The Cavβ subunit prevents RFP2-mediated ubiquitination and proteasomal degradation of L-type channels
Published Date
Dec 26, 2010
Journal
Volume
14
Issue
2
Pages
173 - 180
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