Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.
Abstract
Recently, it was reported that the intraperitoneal administration of 30 mg/kg/day troglitazone to heterozygous superoxide dismutase 2 gene knockout (Sod2+/-) mice for twenty-eight days caused liver injury, manifested by increased serum ALT activity and hepatic necrosis. Therefore, we evaluated the reproducibility of troglitazone-induced liver injury in Sod2+/- mice, as well as their validity as an animal model with higher sensitivity to...
Paper Details
Title
Sensitivity of liver injury in heterozygous Sod2 knockout mice treated with troglitazone or acetaminophen.
Published Date
Feb 1, 2009
Journal
Volume
37
Issue
2
Pages
193 - 200
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