Successful Perioperative Management of Severe Bleeding From Undiagnosed Acquired Factor VIII Inhibitors

ACQUIRED HEMOPHILIA A occurs as a result of development of inhibitory autoantibodies to factor VIII in the coagulation cascade. 1 Franchini M. Lippi G. Acquired factor VIII inhibitors. Blood. 2008; 112: 250-255 Crossref PubMed Scopus (229) Google Scholar These antibodies result in impaired hemostasis and bleeding disorders of variable severities through varied mechanisms including impairment of binding of factor VIII to membrane phospholipids,...