Length of storage and in vitro immunomodulation induced by prestorage leukoreduced red blood cells

BACKGROUND: The relationship between length of storage of red blood cell (RBC) units and biochemical changes has been well studied, but little is known about the progression of cellular immunomodulative properties in blood recipients. This study aims to quantify in vitro T‐cell activation and cytokine release by white blood cells, after incubation with supernatants from leukoreduced RBCs. STUDY DESIGN AND METHODS: Whole blood cultures were...