Runx3 specifies lineage commitment of innate lymphoid cells

Volume: 16, Issue: 11, Pages: 1124 - 1133
Published: Nov 1, 2015
Abstract
Subsets of innate lymphoid cells (ILCs) reside in the mucosa and regulate immune responses to external pathogens. While ILCs can be phenotypically classified into ILC1, ILC2 and ILC3 subsets, the transcriptional control of commitment to each ILC lineage is incompletely understood. Here we report that the transcription factor Runx3 was essential for the normal development of ILC1 and ILC3 cells but not of ILC2 cells. Runx3 controlled the survival...
Paper Details
Title
Runx3 specifies lineage commitment of innate lymphoid cells
Published Date
Nov 1, 2015
Volume
16
Issue
11
Pages
1124 - 1133
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