Standard steroid treatment for autoimmune pancreatitis

Published on Nov 1, 2009in Gut19.819
· DOI :10.1136/GUT.2008.172908
Terumi Kamisawa60
Estimated H-index: 60
(Tokyo Metropolitan Komagome Hospital),
Tooru Shimosegawa69
Estimated H-index: 69
(Tohoku University)
+ 16 AuthorsMasao Omata105
Estimated H-index: 105
(UTokyo: University of Tokyo)
Objective: To establish an appropriate steroid treatment regimen for autoimmune pancreatitis (AIP). Methods: A retrospective survey of AIP treatment was conducted in 17 centres in Japan. The main outcome measures were rate of remission and relapse. Results: Of 563 patients with AIP, 459 (82%) received steroid treatment. The remission rate of steroid-treated AIP was 98%, which was significantly higher than that of patients without steroid treatment (74%, 77/104; p Conclusions: The major indication for steroid treatment in AIP is the presence of symptoms. An initial prednisolone dose of 0.6 mg/kg/day, is recommend, which is then reduced to a maintenance dose over a period of 3–6 months. Maintenance treatment with low-dose steroid reduces but dose not eliminate relapses.
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