A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs

Volume: 111, Issue: 38, Pages: 13817 - 13821
Published: Sep 23, 2014
Abstract
The recent success of antibody–drug conjugates (ADCs) in the treatment of cancer has led to a revived interest in microtubule-destabilizing agents. Here, we determined the high-resolution crystal structure of the complex between tubulin and maytansine, which is part of an ADC that is approved by the US Food and Drug Administration (FDA) for the treatment of advanced breast cancer. We found that the drug binds to a site on β-tubulin that is...
Paper Details
Title
A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs
Published Date
Sep 23, 2014
Volume
111
Issue
38
Pages
13817 - 13821
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