Senescent stroma promotes prostate cancer progression: The role of miR-210

Volume: 8, Issue: 8, Pages: 1729 - 1746
Published: Dec 1, 2014
Abstract
We focused our interest on senescent human-derived fibroblasts in the progression of prostate cancer. Hypoxic senescent fibroblasts promote prostate cancer aggressiveness by inducing epithelial to mesenchymal transition (EMT) and by secreting energy-rich compounds to support cancer cell growth. Hypoxic senescent fibroblasts additionally increase: i) the recruitment of monocytes and their M2-macrophage polarization, ii) the recruitment of bone...
Paper Details
Title
Senescent stroma promotes prostate cancer progression: The role of miR-210
Published Date
Dec 1, 2014
Volume
8
Issue
8
Pages
1729 - 1746
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