NF‐κB is activated from endosomal compartments in antiphospholipid antibodies‐treated human monocytes

BackgroundThe antiphospholipid antibody syndrome (APS) is an autoimmune disease associated with arterial or venous thrombosis and/or recurrent fetal loss and is caused by pathogenic antiphospholipid antibodies (aPLA). We recently demonstrated that Toll‐like receptor 2 (TLR2) and CD14 contribute to monocyte activation of aPLA.ObjectiveTo study the mechanisms of cell activation by aPLA, leading to pro‐coagulant and pro‐inflammatory...