Modulators of estrogen receptor inhibit proliferation and migration of prostate cancer cells
Abstract
In the initial stages, human prostate cancer (PC) is an androgen-sensitive disease, which can be pharmacologically controlled by androgen blockade. This therapy often induces selection of androgen-independent PC cells with increased invasiveness. We recently demonstrated, both in cells and mice, that a testosterone metabolite locally synthetized in prostate, the 5α-androstane-3β, 17β-diol (3β-Adiol), inhibits PC cell proliferation, migration and...
Paper Details
Title
Modulators of estrogen receptor inhibit proliferation and migration of prostate cancer cells
Published Date
Jan 1, 2014
Journal
Volume
79
Pages
13 - 20
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