Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis
Abstract
Osteoarthritis (OA) is a common degenerative condition that afflicts more than 70% of the population between 55 and 77 years of age. Although its prevalence is rising globally with aging of the population, current therapy is limited to symptomatic relief and, in severe cases, joint replacement surgery. We report that intra-articular expression of proteoglycan 4 (Prg4) in mice protects against development of OA. Long-term Prg4 expression under...
Paper Details
Title
Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis
Published Date
Mar 13, 2013
Volume
5
Issue
176
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