Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
Abstract
Adamalysin-like metalloproteinases with thrombospondin (TS) motifs (ADAMTS)-5 is the multi-domain metalloproteinase that most potently degrades aggrecan proteoglycan in the cartilage and its activity is implicated in the development of osteoarthritis (OA). To generate specific exosite inhibitors for it, we screened a phage display antibody library in the presence of the zinc-chelating active site-directed inhibitor GM6001 (Ilomastat) and...
Paper Details
Title
Antibody-based exosite inhibitors of ADAMTS-5 (aggrecanase-2)
Published Date
Oct 16, 2015
Journal
Volume
471
Issue
3
Pages
391 - 401
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Notes
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