Burden of Human Metapneumovirus Infection in Young Children

Published on Feb 13, 2013in The New England Journal of Medicine91.253
· DOI :10.1056/NEJMOA1204630
Mary Allen Staat26
Estimated H-index: 26
BackgroundThe inpatient and outpatient burden of human metapneumovirus (HMPV) infection among young children has not been well established. MethodsWe conducted prospective, population-based surveillance for acute respiratory illness or fever among inpatient and outpatient children less than 5 years of age in three U.S. counties from 2003 through 2009. Clinical and demographic data were obtained from parents and medical records, HMPV was detected by means of a reverse-transcriptase polymerase-chain-reaction assay, and population-based rates of hospitalization and estimated rates of outpatient visits associated with HMPV infection were determined. ResultsHMPV was detected in 200 of 3490 hospitalized children (6%), 222 of 3257 children in outpatient clinics (7%), 224 of 3001 children in the emergency department (7%), and 10 of 770 asymptomatic controls (1%). Overall annual rates of hospitalization associated with HMPV infection were 1 per 1000 children less than 5 years of age, 3 per 1000 infants less than 6...
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