Integrin Inhibitor Suppresses Bevacizumab-Induced Glioma Invasion
Abstract
Glioblastoma is known to secrete high levels of vascular endothelial growth factor (VEGF), and clinical studies with bevacizumab, a monoclonal antibody to VEGF, have demonstrated convincing therapeutic benefits in glioblastoma patients. However, its induction of invasive proliferation has also been reported. We examined the effects of treatment with cilengitide, an integrin inhibitor, on bevacizumab-induced invasive changes in glioma. U87ΔEGFR...
Paper Details
Title
Integrin Inhibitor Suppresses Bevacizumab-Induced Glioma Invasion
Published Date
Apr 1, 2014
Journal
Volume
7
Issue
2
Pages
292 - 302.e1
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