Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion.

Volume: 12, Issue: 5, Pages: 554 - 562
Published: Oct 1, 2000
Abstract
Adhesion of keratinocytes in a wound outgrowth to laminin 5 in the basement membrane via integrins alpha6beta4 and alpha3beta1 is distinct from adhesion to dermal collagen via alpha2beta1 or to fibronectin via alpha5beta1. Leading cells in the outgrowth are distinguished from following keratinocytes by deposition of laminin 5, failure to communicate via gap junctions and sensitivity to toxin B, an inhibitor of RhoGTPase. Laminin 5 deposited by...
Paper Details
Title
Deposition of laminin 5 in epidermal wounds regulates integrin signaling and adhesion.
Published Date
Oct 1, 2000
Volume
12
Issue
5
Pages
554 - 562
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