Synthetic elastase inhibitors: prospects for use in the treatment of emphysema.
Abstract
Human polymorphonuclear leukocyte elastase is the enzyme primarily responsible for the destruction of lung tissue observed in pulmonary emphysema. A number of potent reversible and irreversible inhibitors have been developed for human leukocyte elastase. Several of these inhibitors have been shown to be effective at preventing emphysema in animal models of the disease. There are excellent prospects for the development of a synthetic elastase...
Paper Details
Title
Synthetic elastase inhibitors: prospects for use in the treatment of emphysema.
Published Date
Feb 1, 1983
Journal
Volume
127
Issue
2
Pages
S54 - 8
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Notes
History