Laninamivir's prolonged intrapulmonary retention: Intrapulmonary pharmacokinetics (PK) and the intracellular disposition to support the long-lasting efficacy after an inhaled administration of its prodrug laninamivir octanoate (LO)
Abstract
Background: null A single inhaled dose of LO, a long-acting neuraminidase inhibitor, exhibits efficacy to patients with influenza virus infection. However, the relation between PK and its long-lasting efficacy has not fully been investigated. null null Purpose: null Intrapulmonary PK in healthy volunteers and the intracellular drug disposition in mice were evaluated to support its long-lasting efficacy. null null Methods: null Each subject...
Paper Details
Title
Laninamivir's prolonged intrapulmonary retention: Intrapulmonary pharmacokinetics (PK) and the intracellular disposition to support the long-lasting efficacy after an inhaled administration of its prodrug laninamivir octanoate (LO)
Published Date
Sep 1, 2013
Journal
Volume
42
Pages
727
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