Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI

Volume: 72, Issue: 5, Pages: 1408 - 1417
Published: Nov 1, 2014
Abstract
Purpose A practical, noninvasive method is needed to measure the extracellular pH (pHe) within in vivo tumors to longitudinally monitor tumor acidosis. We have optimized a biomedical imaging method, termed acidoCEST MRI, to provide noninvasive assessments of tumor pHe in preclinical models of mammary carcinoma. Methods A CEST-FISP MRI method was optimized to detect the chemical exchange saturation transfer (CEST) of two amide...
Paper Details
Title
Evaluations of extracellular pH within in vivo tumors using acidoCEST MRI
Published Date
Nov 1, 2014
Volume
72
Issue
5
Pages
1408 - 1417
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