Porous alginate/hydroxyapatite composite scaffolds for bone tissue engineering: Preparation, characterization, and in vitro studies

In this study a series of alginate/hydroxyapatite (HAP) composite scaffolds was prepared by phase separation. HAP was incorporated into the alginate gel solution to improve both the mechanical and cell‐attachment properties of the scaffolds. These scaffolds had a well‐interconnected porous structure with an average pore size of 150 μm and over 82% porosity. The alginate/HAP scaffold prepared at −40°C with a 50% HAP content showed the best...