Angiotensin II stimulates basolateral 50-pS K channels in the thick ascending limb.
Abstract
We used the patch-clamp technique to examine the effect of angiotensin II (ANG II) on the basolateral K channels in the thick ascending limb (TAL) of the rat kidney. Application of ANG II increased the channel activity and the current amplitude of the basolateral 50-pS K channel. The stimulatory effect of ANG II on the K channels was completely abolished by losartan, an inhibitor of type 1 angiotensin receptor (AT1R), but not by PD123319, an...
Paper Details
Title
Angiotensin II stimulates basolateral 50-pS K channels in the thick ascending limb.
Published Date
Mar 1, 2014
Volume
306
Issue
5
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