Transcriptional Signatures of Cellular Plasticity in Mice Lacking the α1 Subunit of GABA_AReceptors

GABA A receptors mediate the majority of inhibitory neurotransmission in the CNS. Genetic deletion of the α1 subunit of GABA A receptors results in a loss of α1-mediated fast inhibitory currents and a marked reduction in density of GABA A receptors. A grossly normal phenotype of α1-deficient mice suggests the presence of neuronal adaptation to these drastic changes at the GABA synapse. We used cDNA microarrays to identify transcriptional...