ADAM-17 Expression in Breast Cancer Correlates with Variables of Tumor Progression
Abstract
The ADAMs are a family of membrane proteins possessing a disintegrin and metalloprotease domain. One of their main functions is shedding of membrane proteins. The aim of this study was to test the hypothesis that ADAM-17 (also known as tumor necrosis factor-α converting enzyme) is involved in breast cancer progression. Overexpression of ADAM-17 in MCF-7 breast cancer cells increased in vitro invasion and proliferation, whereas down-regulation of...
Paper Details
Title
ADAM-17 Expression in Breast Cancer Correlates with Variables of Tumor Progression
Published Date
Apr 15, 2007
Journal
Volume
13
Issue
8
Pages
2335 - 2343
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