An input function estimation method for FDG-PET human brain studies

A new model of an input function for human [(18)F]-2-Deoxy-2-fluoro-d-glucose fluoro (FDG) positron emission tomography (PET) brain studies with bolus injection is presented.Input data for early time, roughly up to 0.6 min, were obtained noninvasively from the time-activity curve (TAC) measured from a carotid artery region of interest. Representative tissue TACs were obtained by clustering the output curves to a limited number of dominant...