Melittin interaction with sulfated sugars and cell membranes
Published: Jan 1, 2008
Abstract
The presented work focused on an alternative mechanism of action of melittin on the
cell membranes. The study using ITC reveals that melittin has a high affinity for several
glycosaminoglycans (GAGs), i.e. heparan sulfate (HS), dermatan sulfate and heparin. The
interaction between peptide and GAGs comprised both electrostatic and non-ionic
components. Circular dichroism (CD) spectroscopy demonstrates that the binding of
melittin to HS and...
Paper Details
Title
Melittin interaction with sulfated sugars and cell membranes
Published Date
Jan 1, 2008
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