A PCR blood test outperforms chromogranin A in carcinoid detection and is unaffected by proton pump inhibitors.
Abstract
A critical requirement in neuroendocrine tumor (NET) management is a blood biomarker test that is sensitive, specific and reproducible. We evaluated a PCR-based 51-transcript signature to detect tumors, compared it with chromogranin A (CgA) and examined the confounding effect of proton pump inhibitors (PPIs), which cause falsely elevated CgA levels. The multigene signature was evaluated in two groups. Group 1: 125 prospectively collected NETs:...
Paper Details
Title
A PCR blood test outperforms chromogranin A in carcinoid detection and is unaffected by proton pump inhibitors.
Published Date
Dec 1, 2014
Journal
Volume
3
Issue
4
Pages
215 - 223
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Notes
History