Role of protein kinase C and phosphoinositide 3‐kinase‐Akt in substance P‐induced proinflammatory pathways in mouse macrophages
Abstract
Neuropeptide modulation of immune cell function is an important mechanism of neuro-immune intersystem crosstalk. Substance P (SP) is one such key neuropeptide involved. In this study, we investigated the yet unexplored cellular mechanisms of SP-mediated inflammatory responses in macrophages using a mouse macrophage-like cell line RAW 264.7 and isolated peritoneal macrophages. We found that the conventional PKCalpha and novel PKCdelta and epsilon...
Paper Details
Title
Role of protein kinase C and phosphoinositide 3‐kinase‐Akt in substance P‐induced proinflammatory pathways in mouse macrophages
Published Date
Nov 24, 2008
Journal
Volume
23
Issue
4
Pages
997 - 1010
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Notes
History