Exploring QSAR for Substituted 2-Sulfonyl-Phenyl-Indol Derivatives as Potent and Selective COX-2 Inhibitors Using Different Chemometrics Tools
Abstract
Selective inhibition of cyclooxygenase‐2 inhibitors is an important strategy in designing of potent anti‐inflammatory compounds with significantly reduced side effects. The present quantitative structure–activity relationship study, attempts to explore the structural and physicochemical requirements of 2‐sulfonyl–phenyl–indol derivatives ( n = 30) for COX‐2 inhibitory activity using chemical, topological, geometrical, and quantum descriptors....
Paper Details
Title
Exploring QSAR for Substituted 2-Sulfonyl-Phenyl-Indol Derivatives as Potent and Selective COX-2 Inhibitors Using Different Chemometrics Tools
Published Date
Nov 19, 2008
Volume
72
Issue
6
Pages
564 - 574
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