Investigation of the abundance and subunit composition of GABAA receptor subtypes in the cerebellum of alpha1-subunit-deficient mice

In cerebellum, 75% of all GABA A receptors contain α1 subunits. Here, we investigated compensatory changes in GABA A receptor subunit expression and composition in α1 subunit‐knockout mice. In these mice the total number of cerebellar GABA A receptors was reduced by 46%. Whereas the number of receptors containing α6 subunits was unchanged, the total amount of α6 subunits was significantly elevated. RT‐PCR showed no increase of α6 mRNA levels,...