Eosinophils as a Novel Cell Source of Prostaglandin D2: Autocrine Role in Allergic Inflammation
Abstract
PGD(2) is a key mediator of allergic inflammatory diseases that is mainly synthesized by mast cells, which constitutively express high levels of the terminal enzyme involved in PGD(2) synthesis, the hematopoietic PGD synthase (H-PGDS). In this study, we investigated whether eosinophils are also able to synthesize, and therefore, supply biologically active PGD(2). PGD(2) synthesis was evaluated within human blood eosinophils, in vitro...
Paper Details
Title
Eosinophils as a Novel Cell Source of Prostaglandin D2: Autocrine Role in Allergic Inflammation
Published Date
Dec 15, 2011
Journal
Volume
187
Issue
12
Pages
6518 - 6526
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