Regulation of Immune Responses by Prostaglandin E2
Abstract
PGE(2), an essential homeostatic factor, is also a key mediator of immunopathology in chronic infections and cancer. The impact of PGE(2) reflects the balance between its cyclooxygenase 2-regulated synthesis and 15-hydroxyprostaglandin dehydrogenase-driven degradation and the pattern of expression of PGE(2) receptors. PGE(2) enhances its own production but suppresses acute inflammatory mediators, resulting in its predominance at late/chronic...
Paper Details
Title
Regulation of Immune Responses by Prostaglandin E2
Published Date
Jan 1, 2012
Journal
Volume
188
Issue
1
Pages
21 - 28
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