Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer

Volume: 22, Issue: 5, Pages: 851 - 861
Published: Oct 1, 2015
Abstract
Excessive exposure to estrogen is a well-established risk factor for endometrial cancer (EC), particularly for cancers of endometrioid histology. The physiological function of estrogen is primarily mediated by estrogen receptor alpha, encoded by ESR1 . Consequently, several studies have investigated whether variation at the ESR1 locus is associated with risk of EC, with conflicting results. We performed comprehensive fine-mapping analyses of...
Paper Details
Title
Comprehensive genetic assessment of the ESR1 locus identifies a risk region for endometrial cancer
Published Date
Oct 1, 2015
Volume
22
Issue
5
Pages
851 - 861
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