CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis

Blood20.30
Volume: 112, Issue: 13, Pages: 5026 - 5036
Published: Dec 15, 2008
Abstract
Cells undergoing apoptosis are efficiently located and engulfed by phagocytes. The mechanisms by which macrophages, the professional scavenging phagocytes of apoptotic cells, are attracted to sites of apoptosis are poorly defined. Here we show that CX3CL1/fractalkine, a chemokine and intercellular adhesion molecule, is released rapidly from apoptotic lymphocytes, via caspase- and Bcl-2-regulated mechanisms, to attract macrophages. Effective...
Paper Details
Title
CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis
Published Date
Dec 15, 2008
Journal
Volume
112
Issue
13
Pages
5026 - 5036
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