FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer

Volume: 13, Issue: 5, Pages: 1046 - 1058
Published: Nov 3, 2015
Abstract
The mesoderm- and epithelial-mesenchymal transition-associated transcription factor FOXC1 is specifically overexpressed in basal-like breast cancer (BLBC), but its biochemical function is not understood. Here, we demonstrate that FOXC1 controls cancer stem cell (CSC) properties enriched in BLBC cells via activation of Smoothened (SMO)-independent Hedgehog (Hh) signaling. This non-canonical activation of Hh is specifically mediated by Gli2....
Paper Details
Title
FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer
Published Date
Nov 3, 2015
Volume
13
Issue
5
Pages
1046 - 1058
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